The course will deal with the following clinical contents: coronary syndromes, heart failure, acute cerebrovascular diseases, arterial hypertension, deep vein thrombosis, pulmonary embolism, thrombophilia, syncope, respiratory failure, anemia, chronic liver disease, inflammatory bowel diseases, malabsorption, autoimmune diseases, renal failure. For each disease the following basic principles will be presented: epidemiology, pathogenesis, risk factors, clinical presentations, main diagnostic approaches, patient management.