BIOCHEMISTRY
Chemistry exam passed
The course aims to provide students with information on the fundamental concepts of biochemistry, including structural biochemistry, the main metabolic cycles and molecules of particular biological interest, such as vitamins, hormones and oxygen transporters. In all the topics, aspects of specific medical interest will be extrapolated, and treated in particular with reference to particular situations of obstetric interest. The course aims to provide a solid base of molecular knowledge on which further concepts related to clinical and theoretical obstetric preparation can be based.
Biomolecules characteristics; Proteins: modifications, allostery; enzymes and their activity controls; Biological Membranes and Transport; The Composition and Architecture of Membranes. Membrane Dynamics. Solute Transport across Membrane. Glucose transport and its regulation. Molecules that can pass the BBB. Haemoglobin and myoglobin. Biosignaling: general features of signal transduction. Bioenergetics and Biochemical Reaction Types. Vitamins and essential molecules. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway. The Metabolism of Glycogen. The Citric Acid Cycle. Digestion, Mobilization, and Transport of lipids. Amino Acid Oxidation and the Production of Urea Metabolic Fates of Amino Groups. Principles of Metabolic Regulation. Analysis of Metabolic Control: insulin and glucagon; AMPK. Synthesis and catabolism of HEME.
Introduzione alla biochimica.
Lehninger, Nelson, Cox.
Terza edizione, 2003.
Zanichelli
Le basi della Biochimica
Champe PC, Harvey RA, Ferrier DR
Zanichelli