MEDICAL SURGICAL BIOTECHNOLOGY AND TECHNOLOGIES - The new technologies of reconstructive and regenerative surgery
- Overview
- Assessment methods
- Learning objectives
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- Full programme
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General histological and anatomical knowledge
oral examination
The course aims to provide students with an advanced understanding of the molecular and genetic mechanisms underlying malignant sinonasal tumors, with particular emphasis on the integration of basic sciences and clinical disciplines.
By the end of the course, students will be able to appreciate the clinical relevance of genetic and molecular profiling of neoplasms for biological classification, prognostic stratification, and therapeutic decision-making.
The course also aims to develop critical skills for interpreting molecular data to guide personalized treatment strategies, identifying high-risk patients who may benefit from treatment intensification, while selecting tailored therapeutic approaches based on tumor-specific biological characteristics, in accordance with the principles of precision medicine.
The course addresses the fundamental concepts of molecular oncology applied to malignant tumors of the sinonasal tract, highlighting the biological and clinical rationale for genetic and molecular profiling of neoplasms.
Key topics include genomic and epigenetic alterations, tumor microenvironment characteristics, and their role in tumor progression, treatment response, and patient prognosis.
Particular emphasis is placed on the translational approach, bridging basic research and clinical practice, and on the evolution of modern therapeutic strategies, including molecularly targeted therapies, immunotherapy, induction chemotherapy, and advanced radiation techniques.
The concept of precision medicine, defined as treatment tailored to the individual patient and to the specific biological features of each tumor, represents the unifying framework of the course.
Extended Program
Principles of precision medicine in molecular oncology
Molecular biology of malignant sinonasal tumors
Diagnostic methodologies for genetic and molecular profiling of neoplasms:
Immunohistochemistry
PCR-based molecular techniques
Fluorescence in situ hybridization (FISH)
Comparative genomic hybridization (CGH) and genomic arrays
Deep sequencing and next-generation sequencing (NGS) technologies
Molecular and biological classification of major sinonasal neoplasms:
Squamous cell carcinoma
Adenocarcinoma
Sinonasal undifferentiated carcinoma
HPV-related neoplasms
Mucosal melanoma
Olfactory neuroblastoma
Sarcomas
Salivary gland tumors and adenoid cystic carcinoma
Correlation between molecular profile, prognosis, and therapeutic strategies
Principles of targeted therapy and patient selection based on actionable molecular alterations
Principles of immunotherapy and the role of the intratumoral inflammatory infiltrate
Biological rationale for induction chemotherapy in poorly differentiated neoplasms
Modern radiation oncology:
Conventional radiotherapy
Advanced radiation modalities using heavy particles (proton beam therapy and carbon ion radiotherapy)
Multidisciplinary integration and future perspectives in the management of sinonasal malignancies
Lectures with slides
The course is designed as a translational course bridging basic sciences and clinical disciplines.