General notions of Pathology:
Etiology (extrinsic causes, mechanisms of action of chemical and physical agents; intrinsic causes, genetic diseases)
Pathogenesis, Morphological and functional modifications
Cellular modifications (causes of cellular damage, necrosis, apoptosis)
Cell growth and differentiation (atrophy, hypertrophy, hypoplasia, hyperplasia, metaplasia)
Inflammation (acute inflammation: vascular and cellular modifications, chemotactic mediators, regeneration and repair of the lesion; chronic inflammation: histology, cellular infiltration, tubercular granuloma)
Inflammation-related diseases: Allergy (type I, II, III, IV), organ specific and systemic autoimmune diseases.
Innate and Adaptive Immunity: lymphoid organs, cells and mediators of the humoral and cellular responses, Major Histocompatibility Complex: polymorphism, function and role in the rejection of transplanted organs. Examples of congenic immunodeficiencies.
Pathogenesis of AIDS
- HIV infection: receptors, co-receptors and cellular targets
- Immune dysfunctions in HIV infection
- Clinical course of HIV infection
Oncology: control of cellular proliferation, anaplasia, tumors classifications; benign and malignant tumors; carcinogenesis: physical and chemical agents, oncogenic viruses; oncogenes and tumor suppressor genes; monoclonality of tumors; multistep carcinogenesis; the metastatic process