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PHYSICAL METHODS IN ORGANIC CHEMISTRY

Degree course: 
Corso di First cycle degree in CHEMICAL AND INDUSTRIAL CHEMISTRY
Academic year when starting the degree: 
2020/2021
Year: 
3
Academic year in which the course will be held: 
2022/2023
Course type: 
Supplementary compulsory subjects
Credits: 
6
Period: 
Second semester
Standard lectures hours: 
48
Detail of lecture’s hours: 
Lesson (48 hours)
Requirements: 

A basic knowledge of organic and physiscal chemistry are prerequisites for this course.

Final Examination: 
Orale

In the final examination, students will be required to attribute 1H and 13C NMR signals of complex organic molecules of knowwn structure. A copy of mono and bidimensionale spectra will be made available to the students and the final evaluation will be determined on the basis of correct structure attribution, interpretation of the coupling constants, and of the bidimensional correlation.
A short oral discussion is foreseen, based on the written examination and aimed at evaluating the knowledge of the NMR principles.

Assessment: 
Voto Finale

Lectures are aimed at providing the students of the third year in Chemistry and Industrial Chemistry with advanced knowledge of NMR spectroscopy. Specifically the following topics will be discussed:
 Physical principles of NMR spectroscopy;
 Application of monodimensional 1H and 13C NMR spectroscopy to the elucidation of chemical structures;
 Pulsed experiments;
 Physical principles of bidimensional homo- and heteronuclear NMR spectroscopy (J-resolved, COSY, HetCor, NOESY experiments).
Students are expected to succeed in:
- Interprete mono- and bidimensional 1H and 13C NMR spectra of organic molecules;

NMR Spectroscopy:
Basic Concepts: The concept of spin and the interaction of spins with external magnetic field and other spins.
Vector description to introduce the concept of free induction decay. Rotating reference frame and RF pulses and its effects. Time and Frequency domains, basic Fourier transform principles. Advanced Tools: Energy levels and NMR spectra
Discussions on spectral features such as, chemical shift, multiplet structures (J coupling), and lineshapes.
One dimensional NMR such as one pulse experiment, spin-echo, and, inversion recovery experiments. Proton and Carbon 1Ds with proton decoupling. Nuclear Magnetic Relaxation: Aspects of relaxation processes. The T1 , T2 , and nuclear Overhauser effect (nOe) stemming from relaxation. Complex pulsed sequences: JMOD, SPT, SPI, INEPT, DEPT.
Two Dimensional NMR: Homonuclear and heteronuclear two-dimensional NMR experiments

NMR Spectroscopy:
Basic Concepts: The concept of spin and the interaction of spins with external magnetic field and other spins.
Vector description to introduce the concept of free induction decay. Rotating reference frame and RF pulses and its effects. Time and Frequency domains, basic Fourier transform principles. Advanced Tools: Energy levels and NMR spectra
Discussions on spectral features such as, chemical shift, multiplet structures (J coupling), and lineshapes.
One dimensional NMR such as one pulse experiment, spin-echo, and, inversion recovery experiments. Proton and Carbon 1Ds with proton decoupling. Nuclear Magnetic Relaxation: Aspects of relaxation processes. The T1 , T2 , and nuclear Overhauser effect (nOe) stemming from relaxation. Complex pulsed sequences: JMOD, SPT, SPI, INEPT, DEPT.
Two Dimensional NMR: Homonuclear and heteronuclear two-dimensional NMR experiments

Classroom lecturing (36 h), Practicals in NMR spectra interpretation (12 h)

Students are encouraged to contact the lecturer by e-mail.

Professors

PIARULLI UMBERTO