INTEGRATED COURSE ON MOLECULAR BASIS OF IMMUNOLOGY AND PATHOLOGIES - Molecular basis of Pathologies
- Overview
- Assessment methods
- Learning objectives
- Contents
- Full programme
- Delivery method
- Teaching methods
- Contacts/Info
The acquisition of the basic principles in the field of cell biology, molecular biology, physiology, biochemistry and immunology is a necessary pre-requisite.
The student must pass an oral exam that concerns questions related to the theoretical aspects of general and molecular pathology; acquisition and understanding of knowledge (40%) and application of acquired knowledge (30%), autonomy of judgment (10%), communication skills (10%) and learning skills (10%).
The course introduces the students to the understanding of the mechanisms and phenomena underlying human pathologies. In particular, the course will allow the students to know the cellular and molecular alterations of the state of health; to know the main exogenous and endogenous drivers of disease; to know the fundamental mechanisms of disease and the biological mechanisms of defense, adaptation to damage, regeneration, and repair. At the end of the course the student must understand how:
i) the etiological agents of disease, whether of an exogenous or endogenous nature, are translated into pathological events through complex cellular and molecular mechanisms.
ii) these mechanisms determine the organism's response to damage: adaptation, cell death.
iii) the state of disease results from the interaction of the causes with the body's cellular and molecular regulatory mechanisms.
iv) the triggering of the pathophysiological regulatory circuits generating/contributing the general pathology.
Basic concepts in pathology: etiology, pathogenesis, clinical significance. General etiology of the disease; hereditary and acquired diseases. Definition and classification of cell injuries/damage.
Cellular responses to stress and harmful stimuli.
Intracellular accumulations and calcifications. Accumulations of water, lipids, proteins, glycogen, pigments. Pathological calcifications: dystrophic and metastatic calcifications.
Genetic diseases.
Acute inflammation: chemical and cellular mediators of inflammation. Outcome of acute inflammation. Morphological patterns of acute inflammation. Chronic inflammation, systemic effects of inflammation, consequences of defective or excessive inflammation.
Tissue repair and regeneration. Cellular and molecular elements involved in healing processes.
Scar and fibrosis. Angiogenesis and vasculogenesis.
Hemodynamic disorders: edema, hyperemia, congestion, hemorrhage, homeostasis and thrombosis, embolism, heart attack, shock.
Atherosclerosis.
Diabetes.
Amyloidosis.
Pathologies of nutrition.
Oncology. Oncogenes and tumor suppressor genes. Classification of tumors. Carcinogenesis and carcinogens. Cancer-related inflammation. Tumor microenvironment and tumor angiogenesis. Immunology of tumors: tumor and immune system interactions, polarization of immune cells.
Seminars.
Basic concepts in pathology: etiology, pathogenesis, clinical significance. General etiology of the disease; hereditary and acquired diseases. Definition and classification of cell injuries/damage.
Cellular responses to stress and harmful stimuli.
Intracellular accumulations and calcifications. Accumulations of water, lipids, proteins, glycogen, pigments. Pathological calcifications: dystrophic and metastatic calcifications.
Genetic diseases.
Acute inflammation: chemical and cellular mediators of inflammation. Outcome of acute inflammation. Morphological patterns of acute inflammation. Chronic inflammation, systemic effects of inflammation, consequences of defective or excessive inflammation.
Tissue repair and regeneration. Cellular and molecular elements involved in healing processes.
Scar and fibrosis. Angiogenesis and vasculogenesis.
Hemodynamic disorders: edema, hyperemia, congestion, hemorrhage, homeostasis and thrombosis, embolism, heart attack, shock.
Atherosclerosis.
Diabetes.
Amyloidosis.
Pathologies of nutrition.
Oncology. Oncogenes and tumor suppressor genes. Classification of tumors. Carcinogenesis and carcinogens. Cancer-related inflammation. Tumor microenvironment and tumor angiogenesis. Immunology of tumors: tumor and immune system interactions, polarization of immune cells.
Seminars.
The course objectives will be achieved through frontal lessons and seminars for a total of 48 hours. Given the extended area and complexity of the topics and the rapid evolution of modern pathology, the attendance to the lessons is highly recommended.
The professor will receive students in his office (Via Monte Generoso 71, "Ex Cascina") after agreeing on an appointment by e-mail.