FARMACOLOGIA GENERALE
PHARMACOLOGY MODULE
Understanding both the general pharmacology module requires basic knowledge of general chemistry and biochemical propagation and organ anatomy and physiology (particularly kidney function, digestive system, cardiovascular function) given in other courses.
PHARMACOLOGY MODULE
The course aims to provide the student with information on the general principles of interaction between human organism and medicines in healthy subjects, patients, and their mechanism of action. Knowledge will also be provided on the setting correct dosing and drug-related risk assessment related to various factors (administration, adverse effects, drug intolerance, and pharmacological interactions), interpretation and application of legislative provisions for the conservation of use of drugs and the development of clinical trials for the discovery of new drugs. The course aims to provide pharmacological and toxicological bases for the management and use of medicines in hospital.
PHARMACOLOGY MODULE
- Pharmacokinetic Exercises. the main routes of drug administration, and the pharmacokinetic processes of absorption, distribution, metabolism and elimination of drugs in healthy subjects, in patients, during pregnancy and in puerperium. Quantitative pharmacokinetic topics will also be used to set a correct dose, such as distribution volume, clearance, half life, maintenance dose, and loading dose. The concept of bioavailability and the equivalent drug will be addressed.
- Pharmacodynamic properties: the main mechanisms underlying drug action. They will also discuss the theoretical basis for the interpretation of drug action by imparting the concepts of agonist, antagonist, partial agonist. Dosage-response curves that allow you to interpret efficacy and pharmacological potency. Drug-toxicology topics will be addressed to interpret toxic drug effects, drug interactions, abuse, tolerance, addiction.
-Examples of pharmaceutical legislation, experimentation. The main laws in force in Italy and the European Union concerning the production, classification of medicines, prescription and pharmacovigilance. Preclinical and clinical studies will also be described for the discovery of new drugs.
• ELEMENTI ESSENZIALI DI FARMACOCINETICA. Birkett DJ. A cura di Marco Cosentino, Piccin Nuova Libraria S.p.A.
• FARMACOLOGIA PER IMMAGINI. ATLANTE TASCABILE. Heinz Lullmann, Klaus Mohr. Centro Scientifico Editore
• FARMACOLOGIA PER LE PROFESSIONI SANITARIE. Conforti A et al., Idelson-Gnocchi
• FARMACOLOGIA – PRINCIPI DI BASE E APPLICAZIONI TERAPEUTICHE. F. Rossi, V. Cuomo, C. Riccardi, Edizioni Minerva Medica