GENERAL PHARMACOLOGY - CO
The comprehension of the Pharmacology course implies a basic knowledge of general chemistry, anatomy, human physiology (renal function, digestive tract, cardiovascular function)
Knowledge of the general principles underlying interaction between human body and drugs and their mechanism of action. In particular, knowledge will be provided on setting correct dosage and evaluating the risk associated with the use of drugs in relation to various factors (route of administration, adverse effects, drug intolerance, pharmacological interactions). In addition, as a result of pharmacological and toxicological knowledge, the ability to manage, preserve and use medicines in a hospital will be transmitted. Knowledge will also be given about the main legislative provisions regarding drug production and use and the preclinical and clinical study of new medicines.
- Pharmacokinetic lineages (7 hours). The main routes of drug administration will be described, and the pharmacokinetic processes of absorption, distribution, metabolism and elimination of drugs in healthy subjects and in patients. Also, some quantitative pharmacokinetic arguments will be used to set a proper dose, such as distribution volume, clearance, half-life, maintenance dose, loading dose. The concept of bioavailability and the equivalent drug will be addressed.
Pharmacodynamic lineages (5 hours): the main mechanisms underlying drug action will be described. It will also discuss the theoretical basis for the interpretation of drug action by imparting the concepts of agonist, antagonist, partial agonist. Dosage-response curves will be described to allow interpretation of efficacy and pharmacological potency. Drug-toxicology topics will be addressed to interpret toxic drug effects, drug interactions, abuse, tolerance, and dependence.
-Pharmaceutical legislation, experimentation (3 hours). The main laws in force in Italy and the European Union concerning the production, classification of medicines, prescription and pharmacovigilance will be described. Preclinical and clinical studies will also be described for the discovery of new drugs.
General and Clinical Pharmacology. Katzung BG. McGraw Hill Lange Ed XIV Ed
Pharmacology. Rang, Dale, Ritter, Flower, Henderson. Elsevier Ed. VII edizione italiana