ORGANIC CHEMISTRY 1
- Overview
- Assessment methods
- Learning objectives
- Contents
- Full programme
- Bibliography
- Delivery method
- Teaching methods
- Contacts/Info
Students are familiar with the principle of general chemistry and in particular with the theory of valence bond, chemical equilibrium and the concept of acidity and basicity according to Broensted-Lowry and Lewis.
Final written examination consisting of a variable number (6-8) of exercises comprising nomenclature and absolute configuration determination, functional group interconversion, conformational analysis
Oral examination consistiong in a variable number of questions aimed at evaluating the comprehension of organic chemistry principle and reactivity.
The course will provide students of the BSc in Chemistry and Industrial Chemistry with a basic knowledge of organic chemistry and in particular of the following topics:
- Organic Nomenclature based on IUPAC rules
- Mechanisms of organic reactions
- Functional groups and their interconversion
By the end of this course students willl be able to:
- Devise synthetic paths for the construction of simple organic molecules
- Discuss mechanistic details of organic transformations applied to specific substrates
- adopt the correct terminology to name organic molecules and describe their reactivity
Atomic Orbitals, hybridization, ionic and covalent bonds, molecular orbitals
Electronegativity and bond polarization. Non bonding interactions, Inductive and resonance effects
Acids and bases in organic chemistry
Main functional groups, their nomenclature and reactivity
Nucleophiles and electrophiles, Carobocations and their transpositions, carbanions and radicals
Principles of organic stereochemistry (molecular symmetry, chirality, stereocentres, absolute and relative configuration descriptors)
Alcanes and cycloalcanes: structure and nomenclature. Concformational analysis of open chains
alkenes and polyenes: geometric isomerism and electrophilic addition (regioselectivity, spereospecificity and stereoselctivity)
Addition of strong and weak acids, alogens, hydroboration, oxymercuriation, oxidation. Reactivity of conjugate dienes: 1,4-addition, Diels-Alder reaction.
Alkynes
Alogenoalkanes: Nucleophilic substitution reaction (Sn1 and Sn2) and elimination (E1 and E2)
Alcohols, ethers and epoxides.
Aldehydes, ketones and their derivatives: addition of water, alcohols, cyanides, cyanides. Aaddition of Grignard reagents. Reactions with ammonia derivatives: imines, enamines, oxymes, hydrazones, acetals, ketals and cyanohydrins. Wittig reactions. Keto-enol tautomerisation: enols, enolates and aldol condensation.
Carboxylix acids and dtheir derivatives: esters, acyl halides, anhydrides, nitriles, amides. Acylic nucleophilic substitution. Claisen condensation, Acetacetic and malonic synthesis. Michael addition
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K. P. C. Vollhardt, N. E. Schore, Chimica organica, 4a Ed. italiana, Zanichelli
N. E. Schore, K. P. C. Vollhardt, Esercizi risolti di chimica organica, Zanichelli
72 lecture hours and 24 hours of practicals
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