RADIOFARMACI E TERAPIA MEDICO NUCLEARE
• General characteristics of radiopharmaceuticals (RP)
Introduction and principles of distribution / localization of radiopharmaceuticals
99mTc in nuclear medical diagnostics
• The Good Manufactoring Practices for Radiopharmaceuticals (GMP – NBP in Nuclear Medicine)
• Radiopharmaceuticals for conventional diagnostic
Classification of RP and composition of cold kits
Classification in generations of RP
Lyophilized kit: composition (e.g. MIBI, molecule structure, ligand, stannous chloride, excipients)
Chemistry of Radiopharmaceuticals with 99mTc and labelling process
• Production cycle of 99mTc
Irradiation of the target
Dissolution of the target and separation
Quality Controls
• Radiolabelling of blood elements WBC, PLT, RBC
• Quality Control of RP
• Positron Emission Radiopharmaceuticals for diagnostics (PET)
Production of radionuclides and synthesis of PET radiopharmaceuticals 18F-FDG, 18F-DOPA, 18F-COLINA
Analogues of somatostatin receptors (68Ga-DOTATOC, 68Ga DOTANOC, 68Ga-DOTATATE)
CQ RP PET
• Radiopharmaceuticals for nuclear medical therapy
1. Fundamentals of Nuclear Medicine (Volterrani, Erba, Mariani)
2. Quality Controls on Radiopharmaceuticals - Thin Layer Chromatography (Lucianini, Menzaghi)
3. Radiopharmaceutical Chemistry (Lewis, Windhorst, Zeglis)
4. Cyclotron Based Production of Technetium-99m (IAEA Radioisotopes and Radiopharmaceuticals Report No.2)
For communications with the teacher, you can use the chat during lessons in Synchronous mode or writing directly to the mail rocco.lucianini@uninsubria.it and/or rocco.lucianini@asst-settelaghi.it phone number 00390332393719