CHEMISTRY AND PREPARATORY BIOCHEMISTRY
- Overview
- Assessment methods
- Learning objectives
- Contents
- Bibliography
- Teaching methods
- Contacts/Info
There are no specific prerequisites, although notions of general chemistry, physics and mathematics can be of help for a faster and more rational understanding of the subject.
1222/5000
In order to verify the learning of the knowledge and skills given in class, a written exam will take place. This examination will be divided into two parts. In the first part, the chemistry exam consists of 25 multiple choice questions (five possible answers, at least one true and to be identified by the student) regarding the comprehension of the topics covered.
In the second part of the exam we provide exercises: recognition of two chemical structures of which the student will write the name, the solution of a simple problem of stoichiometry and finally the student will ask to write two formulas of simple organic molecules (choices between carbohydrates , lipids or amino acids that have been treated in the course).
The final evaluation of the written test will take into account both the multiple choice test (for a maximum of 20 points) and the exercises (for a maximum of 10 points), the result of the examination will be sufficient if the combined results of the two written tests they will exceed the value of 18.
At the request of the students the papers will be available to the students up to seven days after the date of the appeal and then definitively archived for a period of five years.
The integrated course aims to provide the basic knowledge to understand the main biological phenomena at the cellular and tissue level in a chemical and biochemical point of view. The aim of the course is to transmit to the student the understanding of the chemical reactions at the base of life and the role of enzymatic catalysis. The course includes the treatment of the fundamental laws of chemical transformations, of the concept of molecular structure and organization, of spatial orientation, of the role of different molecules in the constitution of biological structures and in the cellular or organism economy, of the main categories of nutrients, and of their value in the context of a proper diet.
Contents and program of the course
Overview of chemistry history. A) Structure of the atom: The nucleus: Nature of the nucleus,. B) Structure of the atom: the electrons. Bohr model, wave nature of electron, stationary wave, orbital shape, quantum numbers, energy levels, orbital energy, electronic configuration of atoms, periodicity of external electronic configuration, periodic properties of elements. C) Heteromonuclear diatomic molecules: Ionic and covalent bonds, Lewis rules, VSEPR theory, chemical bond formation, molecular orbital theory, valence bond theory, distance and bond strength. D) Gaseous State and its laws E) Liquid state and its laws. F) Thermodynamics. Internal energy, Enthalpy, Entropy, Free energy, Free energy and the composition of a system, Chemical equilibrium, thermochemistry, Law of Hess and applications of thermodynamics to biological processes. G) Solutions :. H) Chemical equilibrium I) Acids and Bases :. L) Electrochemistry. M) Chemical kinetics .. N) Inorganic chemistry characteristics of the fundamental elements for medical-biological interest.
ORGANIC CHEMISTRY
A) Carbon hybridization and molecular geometry. B) Alkanes. C) Alkenes:. D) Dieni :. E) Alkines) .F) Cycloalkanes. G) Aromatic hydrocarbons and their main reactions. H) Halogen Derivatives. I) Alcohols and their derivatives. L) Polyalcohols i. M) Thiols and Thiols of biological interest. N) Phenols. O) Aldehydes and ketones. P) Carboxylic acids and derivatives. Q) Amine
BIOCHEMICAL PROPEDEUTICAL
Carbohydrates: nomenclature and classification of aldoses and ketosis, Proteins: Chemical classification of amino acids, reactivity of the carboxylic and aminic group, D-L series and their biological importance. Peptide bond and chemical-physical characteristics. Notes on the structure of proteins, primary, secondary, tertiary and quaternary. Isoelectric point of proteins.
Lipids: Simple lipids: fatty acids, nomenclature. Complex lipids: triglycerides, glycerophospholipids and sphingolipids. Notes on the structure of biological membranes. Cholesterol and its derivatives.
Structure of nucleic acids and nucleotides
Tagliatesta - Chimica generale e inorganica- Ediermes
Botta - Chimica organica - Ediermes
McMurry - Chimica organica un approccio biologica - Zanichelli
Bellini - Chimica medica e prop. biochimica - Zanichelli
Masterton Chimica Piccin
Oral lectures (50 hours) will be imparted to students by using slide projections (usually in Italian but, in cases of recently published material, also in English). During the explanation in the classroom the students are invited to interact with the teachers with questions and curiosity. During the lectures the teachers will also present cases and daily facts that can make understand the application / importance of the subjects of the teachings.
The course also includes hours of supplementary activities (10 hours) dedicated to the study of subjects more related to experimental and laboratory medicine.
Students have the obligation to attend classes as established in the educational regulations of the study course and to sign the time sheet for taking the exam.
Teachers undertake to make projected presentations available to lectures and other material of interest (articles) through the University computer platforms (eg elearning) to which students have access.
In the teacher's presentations there will be links to web pages for further information. For reception students make an appointment by email with the teachers.