The constitutional position of the Regions, their internal discipline and the system of relations with the state, local authorities and the European Union will be illustrated and examined. For a better understanding of the subject, the historical evolution of the regional order in Italy will be traced back to its late establishment and analyzing the successive reforms that led to the current organizational and functional structure, defined in its essential aspects by Constitutional revision laws nn. 1 of 1999, 2 of 2001 and 3 of 2001 and its ordinary implementing laws. The legislative and administrative powers of regional authorities, matters of constitutional order, the current division of competences between the state and the region, and the hermeneutic criteria adopted by the Consulta to resolve these issues of constitutional relevance will be discussed in detail