PRINCIPLES OF ORGANIC SYNTESIS
Prerequisites of the course are simply the basics of organic chemistry, acquired during the core course of the subject during the three-year degree.
The final exam is based on a written test with problems, exercises and questions on the topics discussed in the course and conducted during the lessons.
The course's goal is to introduce some techniques and principles of organic synthesis, even of a more applicative nature, after absorbing those that are the fundamental concepts transmitted in the basic organic chemistry courses. This course is intended to address some of the topics that lead to the expansion of knowledge through some themes that relate to aspects of particular innovation in the field of organic synthesis and which are the subject of recent publications in scientific literature.
Introduction to the Organic Synthesis
Retrosynthesis (concepts, principles, examples and applications
Chemoselectivity
Protecting Groups (protection and deprotection of functional groups in organic synthesis, peptide synthesis)
Rearrangement reactions and Fragmentation processes
Asymmetric Synthesis (chiral auxiliares, chiral catalysts, chiral pool e organocatalysis)
Concepts of Green Chemistry (12 Principles by Anastas and Warner)
Process Chemistry and Intensification in Organic Synthesis (Combinatorial Chemistry, Flow Chemistry)
Multicomponent Reactions
Special topics (scientific literatures, plagiarism, ethical conduct and misconduct, mistakes and experimental errors)
Lectures (48 hours)
During the lectures slides and didactic support will be delivered and here there are only few examples of consultation textbooks.
S. Warren, P. Wyatt - Organic Synthesis: the Disconnection Approach
S. Warren, P. Wyatt - Organic Synthesis: Strategy and Control
E. J. Corey, Xue-Min Cheng - The Logic of Chemical Synthesis
M.B. Smith - Organic Synthesis
The course will be delivered through seminars and lectures on the different topics through various powerpoint presentations.
Some scientifica publications will be illustrated, studied and analyzed during the lectures.