CLINICAL PATHOLOGY
CLINICAL PATHOLOGY
Basic knowledge of biology, cytology, histology and genetics is necessary for understanding the topics discussed in the course. There are no constraints on propedeuticity.
CLINICAL PATHOLOGY
The course provides the general principles and general characteristics of laboratory medicine, with particular reference to the most important clinical aspects and the main analytes of human biological fluids important for health control. Likewise, the basic concepts of the pathophysiology and understanding of the use of laboratory tests in the diagnostic path will be developed.
At the end of the course the student will be able:
1) to know and understand the units of measurement, the importance of collecting and conserving biological samples, pre-analytical variability, sensitivity, specificity and predictive values;
3) to know and understand the characteristics of the major circulating cancer markers, their classification and clinical use, as well as indications of the use of such markers;
2) to develop understanding and description of hematology diagnostic mechanisms; of coagulative and fibrinolytic system; of liver function; of exocrine pancreas; of proteins; of cardiovascular disease; of diabetes and thyroiditis; of renal function; and associated with bone remodeling;
4) understand the notions and principles of vaccination; acute and chronic inflammation, their chemical mediators, and systemic manifestations of inflammation.
The student will also acquire autonomy of judgment and the terminology of laboratory diagnostics.
CLINICAL PATHOLOGY
The front lessons will address the following topics:
Introduction to Laboratory Medicine. Collection and conservation of biological samples: pre-analytical variability. Sensitivity and specificity and predictive values (2h).
Characteristics of the major circulatory markers of cancer, classification and clinical use of tumor markers, as well as indications of the use of such markers (4h).
Protein in diagnostics and indicators of cardiovascular disease (4h).
Diagnostics in hematology: anemia. Coagulative and fibrinolytic system diagnostics (6h).
Inflammation. The two main types of inflammation: acute and chronic and their chemical mediators (2h).
Diagnosis of endocrine disorders: thyroiditis and diabetes mellitus (2h).
Clinical enzyme. Indices of liver function. Exocrine pancreas diagnostics. Lipoproteins and plasma lipids (4h).
Bone remodeling markers and renal function diagnostics (4h).
The vaccines. Basic concepts. Vaccines with killed or live microorganisms and attenuated. Toxoid, conjugated and recombinant synthetic vaccines (2h).
CLINICAL PATHOLOGY
M. Cioffi - Laboratory Diagnostic Manual - Editions Minerva (2010).
Slide lessons: downloadable from the University''s E-learning site.