Biotechnology of signal transduction
To fully understand the topics addressed in the present course, students should possess basic notions of cellular biology and pathology and of general pharmacology
Students will be divided into teams of 1- 2 and asked to prepare a PowerPoint presentation (25-30 minutes in duration, including the discussion on topics that will be assigned during the first weeks of the course. The presentation will be evaluated and graded based on Synthesis, Clarity and Ability to discuss. The final exam consists of an test on selected topic from the syllabus.
The course is designed to provide an updated overview of the molecular mechanism(s) involved in the activation of the different kinds of receptors.
Some topics selected from the syllabus will be assigned to the students who, in teams of 1-2 students each, will prepare an oral presentation that will be presented and discussed at the end of the course in front of the teacher and of their classmates. The topics that are the object of students' presentations are also part of the course program.
At the end of the course, students should be able to:
Understand the mechanisms involved in the activation of receptors.
Understand the role of receptors in cellular adjustments.
Understand the function of signal molecules for the development of biotechnological drugs.
At the end of the course, students should have developed the ability to effectively to research data in the scientific literature, to synthetize them in a PowerPoint and to competently discuss the presented material.
Receptors associated with G-protein
Regulation of CAMP production
Regulation of PKA production
Adjusting the produzone of CREB
Adjusting the production of IP3
Setting up DAG Production
Regulation of PKC production
Receptors with associated kinase activity
Growth factor receptors
Interaction SH2-SH3
RAS functions
Activating the MAP kinase pathway
MYC role
Molecules associated with receptor activation
Cell Cycle Notes
Cell cycle Regulation cell cycle control by the growth factor receptors
Apoptosis receptors
Overview of the molecular mechanisms of apoptosis
TNF-. Alpha receptors
CD40 receptors
Receptors "Scafold "
Functions and regulation of the receptors "Scafold "
Molecules involved in intracellular signaling
NF-Kb role Functions-control
Chemokines receptors.
Role and functions
Students will find the visual materials and articles relevant to the topics presented during the lectures on the Moodle platform, compatibly with the laws on copyright.
Highly recommended reading: Molecular Biology of the cell-5° edition- Alberts
The course consists of ex cathedra lectures, but aims at creating a direct interaction between students and teacher, in order to stir the students' interest concerning the topics of the course.
Lectures and the accompanying visual materials are the major source of information for the student. Thus consistent attendance is recommended; students are also encouraged to further investigate aspects of special interest, by critically searching the literature and the Internet