BIOCHIMICA
No requirements are needed
Biochemistry
The biochemical module aims to provide students with the knowledge of the main classes of biomolecules and to provide an overview of the metabolism with nods to correlte diseases.
The goal is that every student knows the main classes of biomolecules and their metabolic fate and the most common diseases related to it.
Content and course program
Biochemistry
The constituents of biomolecules: sugars, amino acids, lipids, cholesterol, energy molecules. Molecules of reserves, glycogen and triglycerides. Lipid structure, micelles, lipid bilayers, biological membranes and structural properties of cholesterol. Protein peptide bond, amino acid sequence, three-dimensional structure (eg, collagen), post-translational modifications, phosphorylation, glycosylation, proteolytic cleavages (zymogens), coenzymes. Oxygen carriers. Hemoglobin and Myoglobin. Enzymes: properties, kinetics, inhibition, regulation, specificity, nomenclature, enzyme cofactors. Vitamins. Metabolism, generality: anabolism and catabolism, bioenergetics. ATP, substrate phosphorylation, NAD + / FAD, reducing power. Respiratory chain. Glycolysis, glycogen metabolism and effect of insulin and glucagon. Krebs cycle, gluconeogenesis and their regulation. Nitrogen metabolism, Transamination, transdesamination, uric acid and urea cycle. Metabolism of fats and metabolic adaptations in fasting. Catabolism of heme and albumin. Lipoproteins, bile acids and hints on cholesterol metabolism. Generalities on hormones and cyclic AMP, calcium as a second messenger. Intracellular receptors.
Type of educational activities
Lectures
Bibliography
Corso di Biochimica
Michele Samaja
Seconda edizione
Piccin
Assessment methods
The examination for the Assessment will be written and will consist of multiple choice questions and open questions.